PepEvolutionSurvodutide
Boehringer Ingelheim's dual GLP-1/glucagon agonist in phase-3 for obesity and MASH, strong phase-2 signal.
Verdict, C · Emerging / Mixed
A differentiated mechanism with strong phase-2 data in obesity and MASH, but no approval and no verified source. A C pending SYNCHRONIZE readout.
Overview
Survodutide (BI 456906) is a dual GLP-1/glucagon receptor agonist in phase-3 SYNCHRONIZE trials for obesity and metabolic-associated steatohepatitis (MASH). Phase-2 data showed approximately 19% weight loss. MASH is an area of significant unmet need and the glucagon axis adds hepatic benefit beyond GLP-1 alone. No approval exists; no verified gray-market supply.
PepScore Breakdown, the four axes
Evidence
35% weightHow strong is the published human science?
Sourcing & COA
30% weightOur moatCan a buyer obtain an independently-verified, high-purity version?, our proprietary layer.
Safety & Risk
25% weightWhat is the real-world harm potential?
Practicality
10% weightHow easy is it to actually run a verified version?
Sources & Citations
Every claim cites a primary source. Citations are machine-audited against NCBI, see methodology.
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