Growth HormonePreliminary grade

Sermorelin + GHRP-2

The legacy GH-axis stack that preceded CJC/Ipa — functionally similar but GHRP-2's cortisol/prolactin burden makes it a step down.

Verdict — C · Emerging / Mixed

A legacy combination largely superseded by CJC/Ipa. GHRP-2's cortisol and prolactin co-stimulation is a real practical step down from Ipamorelin. Choose CJC/Ipa unless there is a specific clinical reason to prefer this older stack.

PepScore / 100

CEmerging / Mixed

How we compute this →

Overview

Sermorelin + GHRP-2 was the prevailing compounded GH-axis combination before Ipamorelin became widely available. It pairs a GHRH analogue with GHRP-2, a ghrelin mimetic that produces a strong GH pulse but with measurable cortisol and prolactin co-stimulation. The combination is component-derived; no fixed-blend RCT exists. Its primary weakness relative to CJC/Ipa is the GHRP-2 leg — the hormonal side-effect burden is meaningfully higher than Ipamorelin.

PepScore Breakdown — the four axes

Evidence

35% weight

44/100

How strong is the published human science?

Human data depth14/40

Regulatory & registry status12/30

Reproducibility & consistency11/20

Mechanism characterized in humans7/10

Sourcing & COA

30% weightOur moat

54/100

Can a buyer obtain an independently-verified, high-purity version? — our proprietary layer.

Independent 3rd-party testing18/35

Verified purity %16/30

COA transparency & batch traceability11/20

Multi-vendor verified availability9/15

Safety & Risk

25% weight

68/100

What is the real-world harm potential?

Documented AEs / toxicity28/40

Contraindication breadth17/25

Regulatory warnings12/20

Therapeutic index / margin11/15

Practicality

10% weight

68/100

How easy is it to actually run a verified version?

Verified-source availability22/35

Cost / value per cycle16/25

Reconstitution & administration20/25

Storage & stability10/15

Sources & Citations

Every claim cites a primary source. Citations are machine-audited against NCBI — see methodology.

PepScore55/100 · C

Last gradedJune 28, 2026

Next re-grade triggerNo likely grade mover; this combination has been superseded by cleaner formulations.

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Educational only — not medical advice. PepScore is an educational research grade, not a prescription or dosing recommendation. Some vendor links are affiliate links — this never affects grades. Consult a licensed healthcare provider before using any compound.