CognitivePreliminary grade

Semax

A heavily-researched (largely Russian) nootropic/neuroprotective peptide — easy intranasal dosing.

Verdict — B · Viable

A substantial (if largely non-Western) evidence base and easy intranasal dosing; sourcing transparency is the main drag. Viable for the informed.

PepScore / 100

BViable

How we compute this →

Overview

Semax is a synthetic ACTH-derived heptapeptide developed in Russia for stroke and cognitive disorders, and one of the most-studied cognitive peptides — a potent BDNF upregulator. Most clinical data originate outside Western registries; sourcing is moderate.

PepScore Breakdown — the four axes

Evidence

35% weight

49/100

How strong is the published human science?

Human data depth20/40

Regulatory & registry status10/30

Reproducibility & consistency12/20

Mechanism characterized in humans7/10

Sourcing & COA

30% weightOur moat

72/100

Can a buyer obtain an independently-verified, high-purity version? — our proprietary layer.

Independent 3rd-party testing24/35

Verified purity %22/30

COA transparency & batch traceability14/20

Multi-vendor verified availability12/15

Safety & Risk

25% weight

80/100

What is the real-world harm potential?

Documented AEs / toxicity34/40

Contraindication breadth20/25

Regulatory warnings13/20

Therapeutic index / margin13/15

Practicality

10% weight

80/100

How easy is it to actually run a verified version?

Verified-source availability28/35

Cost / value per cycle19/25

Reconstitution & administration22/25

Storage & stability11/15

Sources & Citations

Every claim cites a primary source. Citations are machine-audited against NCBI — see methodology.

→Semax — neuroprotection & BDNF (PubMed)

Best-Sourced Vendor

Limitless Life Nootropics

Vendor 84 · A

Strong vendor grade (A) and the best verified supply right now for Semax — batch-matched independent COA freshness 70%.

Visit Limitless Life Nootropics ↗

Ranked by Source Match = Vendor Grade × batch-COA freshness. Affiliate status is never an input to any grade, and a paying vendor never outranks a non-paying one on a tie.How this works →

PepScore67/100 · B

Last gradedJune 28, 2026

Next re-grade triggerWestern registered trials or broader COA coverage would lift the grade.

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Educational only — not medical advice. PepScore is an educational research grade, not a prescription or dosing recommendation. Some vendor links are affiliate links — this never affects grades. Consult a licensed healthcare provider before using any compound.