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LongevityPreliminary grade

Pinealon

A Russian "short peptide" bioregulator for neuroprotection and aging — almost entirely preclinical and domestic research.

Verdict — D · Speculative

A short-peptide bioregulator whose claims rest on a narrow, largely-unreplicated Russian research base. No specific safety alarm, but the evidence and sourcing simply are not there — Speculative, high caution.

Overview

Pinealon is a synthetic tripeptide (Glu-Asp-Arg) from the Khavinson school of "peptide bioregulators" in Russia, studied for neuroprotection, cognitive function and aging. Its evidence base is almost entirely Russian preclinical and small human work, with limited independent international replication and a mechanism asserted more than demonstrated in human tissue. There is no major safety signal for such short peptides, but the combination of thin, geographically narrow evidence and unverifiable research-grade sourcing keeps it speculative.

PepScore Breakdown — the four axes

Evidence

35% weight
30/100

How strong is the published human science?

Human data depth10/40
Regulatory & registry status6/30
Reproducibility & consistency8/20
Mechanism characterized in humans6/10

Sourcing & COA

30% weightOur moat
46/100

Can a buyer obtain an independently-verified, high-purity version? — our proprietary layer.

Independent 3rd-party testing15/35
Verified purity %14/30
COA transparency & batch traceability9/20
Multi-vendor verified availability8/15

Safety & Risk

25% weight
66/100

What is the real-world harm potential?

Documented AEs / toxicity26/40
Contraindication breadth17/25
Regulatory warnings12/20
Therapeutic index / margin11/15

Practicality

10% weight
60/100

How easy is it to actually run a verified version?

Verified-source availability18/35
Cost / value per cycle16/25
Reconstitution & administration17/25
Storage & stability9/15

Sources & Citations

Every claim cites a primary source. Citations are machine-audited against NCBI — see methodology.

PepScore47/100 · D
Last gradedJune 28, 2026
Next re-grade triggerIndependent international replication or a registered human trial would be needed to move this.

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