Growth HormonePreliminary grade

GHRP-6

The original ghrelin-mimetic GHRP — historically important, outclassed by Ipamorelin on tolerability.

Verdict — D · Speculative

The original GHRP — historically important but outclassed by cleaner options on every practical axis. Prominent hunger and cortisol/prolactin elevation are daily reminders of its limitations. Ipamorelin is a better choice in every scenario where it is available.

PepScore / 100

DSpeculative

How we compute this →

Overview

GHRP-6 is the original ghrelin-mimetic GH secretagogue (Bowers, 1984), producing a strong GH pulse but with prominent hunger stimulation (GI), nausea at higher doses, significant cortisol and prolactin co-stimulation, and a less favorable tolerability profile compared to second- and third-generation GHRPs. It has been largely superseded in the gray-market space by Ipamorelin and GHRP-2 but remains widely catalogued.

PepScore Breakdown — the four axes

Evidence

35% weight

40/100

How strong is the published human science?

Human data depth14/40

Regulatory & registry status8/30

Reproducibility & consistency11/20

Mechanism characterized in humans7/10

Sourcing & COA

30% weightOur moat

45/100

Can a buyer obtain an independently-verified, high-purity version? — our proprietary layer.

Independent 3rd-party testing15/35

Verified purity %13/30

COA transparency & batch traceability9/20

Multi-vendor verified availability8/15

Safety & Risk

25% weight

59/100

What is the real-world harm potential?

Documented AEs / toxicity24/40

Contraindication breadth15/25

Regulatory warnings11/20

Therapeutic index / margin9/15

Practicality

10% weight

62/100

How easy is it to actually run a verified version?

Verified-source availability20/35

Cost / value per cycle14/25

Reconstitution & administration18/25

Storage & stability10/15

Sources & Citations

Every claim cites a primary source. Citations are machine-audited against NCBI — see methodology.

→Bowers C. et al. — GHRP-6 original characterization (Endocrinology 1984)

PepScore48/100 · D

Last gradedJune 28, 2026

Next re-grade triggerNo likely grade mover; compound has been superseded. Only improved sourcing would modestly lift the grade.

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Educational only — not medical advice. PepScore is an educational research grade, not a prescription or dosing recommendation. Some vendor links are affiliate links — this never affects grades. Consult a licensed healthcare provider before using any compound.