PepEvolution5-Amino-1MQ
An NNMT-inhibiting research chemical with compelling mouse fat-loss data — zero human trials, not a peptide.
Verdict — D · Speculative
Mechanistically interesting NNMT inhibitor with striking rodent data, but zero human trials and systemic NNMT involvement creates real uncertainty. Research-chemical territory only — D-grade until human data emerge.
Overview
5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme upregulated in adipose tissue of obese subjects. Mouse studies demonstrate fat-mass reduction without caloric restriction. It is not a peptide and has no registered human clinical trials. The oral route of administration is an advantage, but the absence of any human data and the systemic implications of NNMT inhibition make this a high-uncertainty compound.
PepScore Breakdown — the four axes
Evidence
35% weightHow strong is the published human science?
Sourcing & COA
30% weightOur moatCan a buyer obtain an independently-verified, high-purity version? — our proprietary layer.
Safety & Risk
25% weightWhat is the real-world harm potential?
Practicality
10% weightHow easy is it to actually run a verified version?
Sources & Citations
Every claim cites a primary source. Citations are machine-audited against NCBI — see methodology.
Educational only — not medical advice. PepScore is an educational research grade, not a prescription or dosing recommendation. Some vendor links are affiliate links — this never affects grades. Consult a licensed healthcare provider before using any compound.