Evidence-based articles on peptide science — from beginner introductions to clinician-grade regulatory analysis. Every article is cited. No hype, no dosing prescriptions.
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GHK-Cu is a naturally occurring tripeptide that declines with age and modulates over 4,000 human genes involved in tissue repair, antioxidant defense, and regeneration. Here is what the peer-reviewed research actually shows.
GHRP-2 and GHRP-6 are synthetic ghrelin mimetics that trigger pulsatile growth hormone release at the pituitary. Here's what the peer-reviewed research actually shows about how they differ, where the science is solid, and where the evidence runs thin.
Sermorelin is a 29-amino-acid analog of endogenous GHRH that stimulates your own pituitary to release growth hormone rather than replacing it externally. Here's the mechanism, what the research actually shows, and how it compares to CJC-1295.
Selank is a synthetic heptapeptide derived from tuftsin, approved in Russia for generalized anxiety disorder and studied for cognitive enhancement and immune modulation. Here's what the peer-reviewed evidence actually shows — and what its shifting regulatory status means in 2026.
Thymosin Alpha-1 (Tα1) is an endogenous thymic peptide with a 40-year clinical evidence base spanning viral hepatitis, sepsis, cancer immunotherapy, and COVID-19. Here is a mechanistic and evidence-based overview for clinicians navigating its current regulatory landscape.
Muscle loss on semaglutide or tirzepatide is a real concern — but the data is more nuanced than headlines suggest. Here's what major clinical trial DXA substudies actually found, and what the emerging evidence says about protecting lean mass.
IGF-1 LR3 is a synthetic analog of insulin-like growth factor-1 engineered to evade binding proteins and extend its half-life. Here's an honest look at the preclinical mechanisms, what researchers have found, and why the fitness world is paying attention.
MOTS-c is a 16-amino-acid peptide encoded inside mitochondrial DNA — not nuclear DNA. Discovered in 2015, it acts as an exercise-responsive metabolic regulator with compelling preclinical data for insulin sensitivity, muscle health, and longevity. Here's an honest look at where the science stands.
Epitalon is a synthetic tetrapeptide studied for telomere elongation, melatonin restoration, and geroprotective effects. Here's an honest breakdown of the science — what's compelling, what's still limited, and what makes this compound worth watching.
AOD-9604 is a synthetic fragment of human growth hormone engineered to isolate its fat-burning properties without the side effects of full HGH. Here's what the research actually shows — and where the evidence runs thin.
The first head-to-head randomized trial comparing tirzepatide and semaglutide for weight loss is in. Here's what SURMOUNT-5 found — and what the full body of evidence tells us about how these two peptide therapies compare.
Safety is the first question anyone should ask about peptides. Here's an honest, evidence-based look at what we know, what we don't know, and how to think about risk when evaluating peptide use.
The regulatory framework governing compounded peptides is undergoing its most significant changes in a decade. Here's the authoritative breakdown of 503A vs. 503B, the PCAC July 2026 review, and what it means for practitioners and patients.
GLP-1 receptor agonists like semaglutide and tirzepatide are famous for weight loss, but the science reveals a far richer picture — cardiovascular protection, neurological effects, and metabolic benefits that go well beyond the scale.
Growth hormone secretagogues like Ipamorelin and CJC-1295 work by stimulating your body's own GH release rather than replacing it externally. Here's how they work, how they differ, and what the research shows.
BPC-157 and TB-500 are the two most-discussed recovery peptides in athletic and fitness circles. Here's what the research actually says about how they work, why they're often stacked, and what the evidence looks like.
A Certificate of Analysis (COA) is your best tool for evaluating peptide vendor quality. Learn what a real COA contains, what red flags to look for, and how to verify a vendor isn't faking their testing.
BPC-157 is one of the most-discussed research peptides in wellness communities — but what is it actually? This plain-language guide explains the science, what researchers have studied, and what you should know.
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